Quick Fib – Projects – Pioneer Fund – Technische Universität Darmstadt

QuickFib – A rapid test for determination of fibrinogen for the targeted treatment of fibrinogen deficiency states

The blood coagulation is an essential process that is precisely controlled in the body to avoid both blood loss and thrombosis. During coagulation fibrinogen is converted to fibrin that aggregates to form a blood clot and thus stops the bleeding. During bleeding events, the plasma concentration of fibrinogen decreases much faster than that of all other coagulation factors. The resulting fibrinogen depletion may be life-threatening and lead to bleeding death.

The project team has developed a concept for an enzyme-based rapid test to determine the fibrinogen concentration in 2-5 minutes. The goal of the Pioneer Project is the development of a reliable rapid test on the basis of cuvettes. Such a test is the starting point for the further development of a marketable test strip with a corresponding reading device with digital output which is licensed as in-vitro-diagnostics according the Medizinproduktegesetz (German federal law for medical devices).

Project Kick-Off 2017. Persons from left to right: M.Sc. Veysel Erdel (project team), Dr. Joachim Hönes (project team), Prof. Dr. Katja Schmitz (head of project), M.Sc. Robert Heitzmann (Innovation Manager of TU Darmstadt, Pioneer Fund).
Project Kick-Off 2017. Persons from left to right: M.Sc. Veysel Erdel (project team), Dr. Joachim Hönes (project team), Prof. Dr. Katja Schmitz (head of project), M.Sc. Robert Heitzmann (Innovation Manager of TU Darmstadt, Pioneer Fund).

Fast analysis of the plasma level of fibrinogen in bleeding patients can save lifes.

Figure 1: Acute blood loss, blood coagulation at great wound areas or lack of fibrinogen production in the liver can lead to fibrinogen deficiency. Rapid determination of the fibrinogen level allows a targeted therapy.
Figure 1: Acute blood loss, blood coagulation at great wound areas or lack of fibrinogen production in the liver can lead to fibrinogen deficiency. Rapid determination of the fibrinogen level allows a targeted therapy.

There is an urgent need for a rapid test with high precision in the relevant concentration range.

Figure 2: The rapid determination of the fibrinogen level enables a targeted treatment. The innovation, an enzyme-based rapid test with internal interference compensation, rapidly provides the basis of a therapeutic decision. (Image: David-i98, "Blood Glucose Testing", source: https://en.wikipedia. org /w/index.php?curid=11556337, CC BY-SA 3.0, https://creativecommons.org/licenses/by-sa/3.0/de/)
Figure 2: The rapid determination of the fibrinogen level enables a targeted treatment. The innovation, an enzyme-based rapid test with internal interference compensation, rapidly provides the basis of a therapeutic decision. (Image: David-i98, “Blood Glucose Testing”, source: https://en.wikipedia. org /w/index.php?curid=11556337, CC BY-SA 3.0, https://creativecommons.org/licenses/by-sa/3.0/de/)