Ultra-high resolution 3D printing system based on two-photon polymerization for the study of biosynthetic blood vessel networks

The state-of-the-art two-photon printer can produce microscopic 3D objects with a resolution of less than 1 µm in a very short time. Based on two-photon polymerization, extremely fine and detailed objects can be produced for a wide range of applications, e.g. microfluidics and nano optics, but also for advanced cell culture applications.

As part of the LOEWE research focus FLOW FOR LIFE, the printing system will be used for the production of complex branched biosynthetic blood vessels. In combination with 3D bioprinting technology, these will serve as the basis for the biofabrication of macroscopic tissue models. By integrating the biosynthetic vessels, the exchange of nutrients and respiratory gases should enable the cultivation of organoids several millimeters in size in the future.