FLOW FOR LIFE offers a very interactive PhD and Postdoc community with possibilities to work in different labs of our consortium as well as short-term stays abroad.
As a PhD student, you will follow a structured PhD program. As a Postdoc, you will be supported by an extra budget (Postdoc bonus) for own research initiatives. PhD students and Postdocs will take part in symposia and other activities including contacts to industry partners. FLOW FOR LIFE prepares you both for an academic and an industry career.
The TU Darmstadt is a family-friendly University and aims to increase the proportion of women among its staff. We particularly encourage women to join our research cluster!
Some of the following positions are advertised on the job portal of the Technical University of Darmstadt.
Simulation and optimization of bio-/microfluidic networks (PhD position, Steffen Hardt)
The overarching task of our project is to understand and optimize the distribution of nutrient and oxygen inside and outside of a microfluidic network, designed to supply a 3D cell cluster. The final goal is to design a network that efficiently mimics the vascular system of tissues.
Flow Characterisation in Artificial Networks (PhD position, Jeanette Hussong, Mechanical Engineering)
At the institute of Fluid Mechanics and Aerodynamics, the flow in artificial networks will be characterized in detail by means of optical laser measurement techniques. The aim of this project is to better understand the transport processes and the interaction between nutrient supply in the network and cell growth.
High resolution 3D-printing (Postdoc position, Andreas Blaeser and Steffen Hardt, Mechanical Engineering)
This project is a collaborative effort between the groups of Andreas Blaeser and Steffen Hardt. 2-photon polymerization-based 3D-printing processes will be used for the fabrication of complex, branched vascular networks. Printed objects will be characterized mechanically, optically, and biologically. Furthermore, new bioreactor concepts for the integration of the generated networks will be developed.
Dynamic control of oxygen saturation in nutrition solution (PhD position, Bastian Etzold, Chemistry)
In this project, the oxygen saturation and transport in nutrition solution as well as direct oxygen generation through electrolysis will be studied. An automated saturator needs to be designed and validated and kinetics of the oxygen transport need to be studied experimentally.
Microgels (PhD position, Regine v. Klitzing, Physics)
In this project, microgels as bonding agents between endothelial cells and the artificial network will be designed. This involves the synthesis of microgels and their characterization with light shattering and electron microscopy. The adsorption and the nanomechanics / nanorheology will be studied with Atomic Force Microscopy. There will be a close interdisciplinary collaboration with the other FLOW FOR LIFE groups, i.e. biologists, chemists and engineers.
Assembly of hydrogel formulations (PhD position, Andreas Blaeser, Mechanical Engineering)
In this project, the interaction of printing processes, bioinks and nozzle shear stress on cell functionality will be investigated. Printing processes and printing-related components will be developed and tested. New bioink formulations and methods for the gentle dispensing of living cells will be developed and characterized.
3D cell aggregates and endothelialisation (Postdoc position, Ulrike Nuber, Biology)
Vascularized stem cell-derived 3D tissue building blocks of improved spatial organization will be developed in this project. The project involves a broad spectrum of state-of-the-art molecular and cellular technologies. There will be particularly close interactions with the Blaeser group regarding hydrogel formulations for 3D cell aggregates, with Regine v. Klitzing´s group on endothelial cell – microgel adhesion and with Cristina Cardoso´s group on 3D microscopy.
3D microscopy (50% Postdoc position, M. Cristina Cardoso, Biology)
The project involves establishing clearing and sample preparation protocols combined with detection of differentiated cell types in organ-like samples up to the centimeter size range using light sheet microscopy. Close interactions will take place with Ulrike Nuber’s group regarding the organ-like culture material and with Heinz Koeppl’s group regarding 3D image analysis and modeling. Additional interactions are expected with several of the groups developing the scaffold systems the groups as well as the culture chamber and nutrient+oxygen supply.